| May 18 | Sinclair Andrew | Director | DTOISS◆ | 10,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 2,124 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 635 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 823 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS◆ | 1,333 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Sinclair Andrew | Director | DTOISS | 10,491 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 10,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 2,124 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 2,666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 635 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS◆ | 1,333 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Volck Birgitte | Director | DTOISS | 17,536 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 11,900 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 13,800 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 16,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 55,392 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 11,667 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 2,445 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 18,800 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 666 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 4,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 4,999 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS◆ | 1,741 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Yen Kristen | See Remarks | DTOISS | 37,639 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Pauls Matthew | Director | DTOISS◆ | 9,063 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Pauls Matthew | Director | DTOISS | 10,491 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Norrett Kevin | Chief Business Officer | DTOISS◆ | 4,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Norrett Kevin | Chief Business Officer | DTOISS◆ | 64,286 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Norrett Kevin | Chief Business Officer | DTOISS | 17,786 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Manning Meredith | Chief Commercial Officer | DTOISS◆ | 32,800 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Manning Meredith | Chief Commercial Officer | DTOISS◆ | 29,200 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Manning Meredith | Chief Commercial Officer | DTOISS◆ | 91,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Manning Meredith | Chief Commercial Officer | DTOISS | 64,507 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Joshi Manher | Chief Development… | DTOISS◆ | 4,700 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Joshi Manher | Chief Development… | DTOISS◆ | 72,321 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Joshi Manher | Chief Development… | DTOISS | 20,171 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Huang Michael F. | Sr. VP of Clinical… | DTOISS◆ | 11,900 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Huang Michael F. | Sr. VP of Clinical… | DTOISS◆ | 13,800 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Huang Michael F. | Sr. VP of Clinical… | DTOISS◆ | 110,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Huang Michael F. | Sr. VP of Clinical… | DTOISS | 39,823 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 1,333 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 11,900 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 13,800 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 16,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 49,262 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 11,667 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 2,445 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 18,842 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS◆ | 2,333 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Hirano Patricia C | See Remarks | DTOISS | 22,702 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Hahn Mark W | Director | DTOISS | 10,046 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Fulk Jennifer | Chief Financial Officer | DTOISS◆ | 67,660 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Fulk Jennifer | Chief Financial Officer | DTOISS | 39,200 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Bir Dawn Carter | Director | DTOISS | 16,991 | — | — | -100.0% | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 131,400 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 115,600 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 100,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 200,753 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 52,709 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 73,333 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 8,473 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 35,000 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 23,332 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 60 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS◆ | 22,452 | — | — | — | ↗Open the original filing on SEC.gov |
| May 18 | Anish Bhatnagar | Chief Executive Officer | DTOISS | 583,656 | — | — | -100.0% | ↗Open the original filing on SEC.gov |