XLO

Xilio Therapeutics, Inc.

Insider trading activity for Xilio Therapeutics, Inc., straight from SEC Form 4 filings. Net figures below count open-market buys and sales only — grants, option exercises and tax withholding are excluded because they are compensation, not decisions to trade.

Past 3 months

net buying

Bought(0 · 0 insiders): $0
Sold(0 · 0 insiders): $0

Past 6 months

net buying

Bought(0 · 0 insiders): $0
Sold(0 · 0 insiders): $0

Past 12 months

+$38.3K

net buying

Bought(1 · 1 insiders): $44K
Sold(2 · 2 insiders): $5.7K

Transaction history

The 96 most recent Form 4 transactions.

Open in screener →

Insider transactions, newest first: date, security, transaction type, size and a link to the filing each row came from.
Date	Insider	Role	Type	Shares	Price	Value	Δ Own	Filing
Jun 11	Xu Yuan	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Shannon James Samuel	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Ross Robert W.	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Curran Daniel J.	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Brennan Aoife	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Bonstein Sara	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Jun 11	Bello Akintunde…	Director	AGRANT◆	5,000	—	—	—	Open the original filing on SEC.gov
Apr 15	Blanchard Cheryl R	Director	AGRANT◆	10,000	—	—	—	Open the original filing on SEC.gov
Mar 26	Shannon James Samuel	Director	PBUY	5,000	$8.79	$44K	+100.0%	Open the original filing on SEC.gov
Feb 13	Gilead Sciences, Inc.	10% Owner	PDBUY◆	3.7M	$0.5349	$2M	—	Open the original filing on SEC.gov
Jan 2	Frankenfield Christopher…	Chief Financial Officer	SSELL◷	7,030	$0.6432	$4.5K	-22.1%	Open the original filing on SEC.gov
Jan 2	Brennan Kevin M.	SVP, Finance and…	SSELL◷	1,826	$0.6432	$1.2K	-22.3%	Open the original filing on SEC.gov
Jan 1	Russo Rene	President and CEO	MEXER◆	44,250	—	—	—	Open the original filing on SEC.gov
Jan 1	Russo Rene	President and CEO	MEXER	44,250	—	—	+15.7%	Open the original filing on SEC.gov
Jan 1	Luptakova Katarina	Chief Medical Officer	MEXER◆	16,625	—	—	—	Open the original filing on SEC.gov
Jan 1	Luptakova Katarina	Chief Medical Officer	MEXER	16,625	—	—	+100.0%	Open the original filing on SEC.gov
Jan 1	Frankenfield Christopher…	Chief Financial Officer	MEXER◷◆	19,375	—	—	—	Open the original filing on SEC.gov
Jan 1	Frankenfield Christopher…	Chief Financial Officer	MEXER◷	19,375	—	—	+156.0%	Open the original filing on SEC.gov
Jan 1	Brennan Kevin M.	SVP, Finance and…	MEXER◷◆	5,000	—	—	—	Open the original filing on SEC.gov
Jan 1	Brennan Kevin M.	SVP, Finance and…	MEXER◷	5,000	—	—	+156.4%	Open the original filing on SEC.gov
Dec 31, 2025	Russo Rene	President and CEO	AGRANT◆	1.5M	—	—	—	Open the original filing on SEC.gov
Dec 31, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	451,885	—	—	—	Open the original filing on SEC.gov
Dec 31, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◷◆	668,789	—	—	—	Open the original filing on SEC.gov
Dec 31, 2025	Brennan Kevin M.	SVP, Finance and…	AGRANT◷◆	95,221	—	—	—	Open the original filing on SEC.gov
Nov 26, 2025	Gilead Sciences, Inc.	10% Owner	XXITM◆	13.3M	—	—	—	Open the original filing on SEC.gov
Nov 26, 2025	Gilead Sciences, Inc.	10% Owner	XXITM◆	13.3M	$0.7499	$10M	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	700,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	700,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	350,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	350,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	150,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	150,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	100,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	100,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	50,041	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	50,041	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	135,134	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	135,134	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	473,334	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	473,334	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	239,703	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	DTOISS◆	239,703	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Russo Rene	President and CEO	AGRANT◆	2.1M	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	106,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	DTOISS◆	106,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	DTOISS◆	25,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	35,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	DTOISS◆	35,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	15,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	DTOISS◆	15,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	44,210	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	DTOISS◆	44,210	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Luptakova Katarina	Chief Medical Officer	AGRANT◆	625,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	300,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	300,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	150,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	150,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	117,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	117,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	20,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	20,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	45,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	45,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	37,296	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	37,296	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	23,786	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	23,786	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	155,090	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	DTOISS◆	155,090	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	925,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	AGRANT◆	20,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	DTOISS◆	20,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	DTOISS◆	25,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	AGRANT◆	55,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	DTOISS◆	55,000	—	—	—	Open the original filing on SEC.gov
Nov 21, 2025	Brennan Kevin M.	SVP, Finance and…	AGRANT◆	131,700	—	—	—	Open the original filing on SEC.gov
Jun 17, 2025	Shannon James Samuel	Director	PBUY	25,000	$0.6886	$17.2K	+55.6%	Open the original filing on SEC.gov
Jun 16, 2025	Shannon James Samuel	Director	PBUY	45,000	$0.686	$30.9K	—	Open the original filing on SEC.gov
Jun 16, 2025	Russo Rene	President and CEO	PBUY	36,289	$0.6801	$24.7K	+14.8%	Open the original filing on SEC.gov
Jun 11, 2025	Xu Yuan	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Shannon James Samuel	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Rossi Christina	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Ross Robert W.	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Curran Daniel J.	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Clancy Paul J	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Brennan Aoife	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 11, 2025	Bonstein Sara	Director	AGRANT◆	31,000	—	—	—	Open the original filing on SEC.gov
Jun 10, 2025	Bello Akintunde…	Director	AGRANT◆	62,000	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Gilead Sciences, Inc.	10% Owner	PDBUY◆	13.3M	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Gilead Sciences, Inc.	10% Owner	PDBUY◆	13.3M	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Gilead Sciences, Inc.	10% Owner	PDBUY◆	13.3M	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Gilead Sciences, Inc.	10% Owner	PDBUY◆	13.3M	—	—	—	Open the original filing on SEC.gov
Apr 15, 2025	Russo Rene	President and CEO	AGRANT◆	190,000	—	—	—	Open the original filing on SEC.gov
Apr 15, 2025	Frankenfield Christopher…	Chief Financial Officer	AGRANT◆	75,000	—	—	—	Open the original filing on SEC.gov

AGRANT◆—

Xu Yuan · DirectorJun 11

5,000 sh

AGRANT◆—

Shannon James Samuel · DirectorJun 11

5,000 sh

AGRANT◆—

Ross Robert W. · DirectorJun 11

5,000 sh

AGRANT◆—

Curran Daniel J. · DirectorJun 11

5,000 sh

AGRANT◆—

Brennan Aoife · DirectorJun 11

5,000 sh

AGRANT◆—

Bonstein Sara · DirectorJun 11

5,000 sh

AGRANT◆—

Bello Akintunde… · DirectorJun 11

5,000 sh

AGRANT◆—

Blanchard Cheryl R · DirectorApr 15

10,000 sh

PBUY$44K

Shannon James Samuel · DirectorMar 26

5,000 sh @ $8.79 · +100.0% own

PDBUY◆$2M

Gilead Sciences, Inc. · 10% OwnerFeb 13

3.7M sh @ $0.5349

SSELL◷$4.5K

Frankenfield Christopher… · Chief Financial…Jan 2

7,030 sh @ $0.6432 · -22.1% own

SSELL◷$1.2K

Brennan Kevin M. · SVP, Finance and…Jan 2

1,826 sh @ $0.6432 · -22.3% own

MEXER◆—

Russo Rene · President and CEOJan 1

44,250 sh

MEXER—

Russo Rene · President and CEOJan 1

44,250 sh · +15.7% own

MEXER◆—

Luptakova Katarina · Chief Medical…Jan 1

16,625 sh

MEXER—

Luptakova Katarina · Chief Medical…Jan 1

16,625 sh · +100.0% own

MEXER◷◆—

Frankenfield Christopher… · Chief Financial…Jan 1

19,375 sh

MEXER◷—

Frankenfield Christopher… · Chief Financial…Jan 1

19,375 sh · +156.0% own

MEXER◷◆—

Brennan Kevin M. · SVP, Finance and…Jan 1

5,000 sh

MEXER◷—

Brennan Kevin M. · SVP, Finance and…Jan 1

5,000 sh · +156.4% own

AGRANT◆—

Russo Rene · President and CEODec 31, 2025

1.5M sh

AGRANT◆—

Luptakova Katarina · Chief Medical…Dec 31, 2025

451,885 sh

AGRANT◷◆—

Frankenfield Christopher… · Chief Financial…Dec 31, 2025

668,789 sh

AGRANT◷◆—

Brennan Kevin M. · SVP, Finance and…Dec 31, 2025

95,221 sh

XXITM◆—

Gilead Sciences, Inc. · 10% OwnerNov 26, 2025

13.3M sh

XXITM◆$10M

Gilead Sciences, Inc. · 10% OwnerNov 26, 2025

13.3M sh @ $0.7499

AGRANT◆—