SYRE

Spyre Therapeutics, Inc.

Insider trading activity for Spyre Therapeutics, Inc., straight from SEC Form 4 filings. Net figures below count open-market buys and sales only — grants, option exercises and tax withholding are excluded because they are compensation, not decisions to trade.

Past 3 months

-$412.4M

net selling

Bought(0 · 0 insiders): $0
Sold(29 · 6 insiders): $412.4M

Past 6 months

-$426M

net selling

Bought(0 · 0 insiders): $0
Sold(47 · 6 insiders): $426M

Past 12 months

-$426M

net selling

Bought(0 · 0 insiders): $0
Sold(47 · 6 insiders): $426M

Transaction history

The 73 most recent Form 4 transactions.

Open in screener →

Date	Insider	Role	Type	Shares	Price	Value	Δ Own	Filing
Aug 7	Albers Jeffrey W.	Director	MEXER◷◆	5,000	—	—	—	Open the original filing on SEC.gov
Aug 7	Albers Jeffrey W.	Director	SSELL◷	10,000	$104.68	$1M	-51.6%	Open the original filing on SEC.gov
Aug 7	Albers Jeffrey W.	Director	SSELL◷	8,000	$104.38	$835K	-29.2%	Open the original filing on SEC.gov
Aug 7	Albers Jeffrey W.	Director	SSELL◷	5,000	$104.47	$522.4K	-100.0%	Open the original filing on SEC.gov
Aug 7	Albers Jeffrey W.	Director	MEXER◷	5,000	$10.39	$52K	—	Open the original filing on SEC.gov
Aug 3	Turtle Cameron	Chief Executive Officer	SSELL◷	16	$97.46	$1.6K	0.0%	Open the original filing on SEC.gov
Aug 3	Turtle Cameron	Chief Executive Officer	SSELL◷	1,392	$96.82	$134.8K	-0.2%	Open the original filing on SEC.gov
Aug 3	Turtle Cameron	Chief Executive Officer	SSELL◷	5,635	$95.93	$540.6K	-1.0%	Open the original filing on SEC.gov
Aug 3	Turtle Cameron	Chief Executive Officer	SSELL◷	7,157	$95.10	$680.6K	-1.2%	Open the original filing on SEC.gov
Aug 3	Turtle Cameron	Chief Executive Officer	SSELL◷	800	$93.97	$75.2K	-0.1%	Open the original filing on SEC.gov
Aug 3	Burrows Scott L	Chief Financial Officer	MEXER◷◆	7,500	—	—	—	Open the original filing on SEC.gov
Aug 3	Burrows Scott L	Chief Financial Officer	SSELL◷	100	$97.10	$9.7K	-0.1%	Open the original filing on SEC.gov
Aug 3	Burrows Scott L	Chief Financial Officer	SSELL◷	2,300	$96.30	$221.5K	-2.3%	Open the original filing on SEC.gov
Aug 3	Burrows Scott L	Chief Financial Officer	SSELL◷	5,100	$95.21	$485.6K	-4.8%	Open the original filing on SEC.gov
Aug 3	Burrows Scott L	Chief Financial Officer	MEXER◷	7,500	$14.50	$108.8K	+7.6%	Open the original filing on SEC.gov
Jul 1	Turtle Cameron	Chief Executive Officer	SSELL◷	590	$88.91	$52.5K	-0.1%	Open the original filing on SEC.gov
Jul 1	Turtle Cameron	Chief Executive Officer	SSELL◷	4,234	$88.12	$373.1K	-0.7%	Open the original filing on SEC.gov
Jul 1	Turtle Cameron	Chief Executive Officer	SSELL◷	10,176	$87.44	$889.8K	-1.7%	Open the original filing on SEC.gov
Jul 1	Sloan Sheldon	Chief Medical Officer	MEXER◷◆	8,334	—	—	—	Open the original filing on SEC.gov
Jul 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	1,834	$88.34	$162K	-100.0%	Open the original filing on SEC.gov
Jul 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	6,500	$87.52	$568.9K	-78.0%	Open the original filing on SEC.gov
Jul 1	Sloan Sheldon	Chief Medical Officer	MEXER◷	8,334	$27.46	$228.9K	—	Open the original filing on SEC.gov
Jul 1	Burrows Scott L	Chief Financial Officer	MEXER◷◆	7,500	—	—	—	Open the original filing on SEC.gov
Jul 1	Burrows Scott L	Chief Financial Officer	SSELL◷	1,725	$88.37	$152.4K	-1.7%	Open the original filing on SEC.gov
Jul 1	Burrows Scott L	Chief Financial Officer	SSELL◷	5,775	$87.55	$505.6K	-5.5%	Open the original filing on SEC.gov
Jul 1	Burrows Scott L	Chief Financial Officer	MEXER◷	7,500	$14.50	$108.8K	+7.6%	Open the original filing on SEC.gov
Jun 25	Burrows Scott L	Chief Financial Officer	MEXER◆	15,000	—	—	—	Open the original filing on SEC.gov
Jun 25	Burrows Scott L	Chief Financial Officer	SSELL	10,000	$87.14	$871.4K	-9.3%	Open the original filing on SEC.gov
Jun 25	Burrows Scott L	Chief Financial Officer	SSELL	5,000	$87.12	$435.6K	-4.4%	Open the original filing on SEC.gov
Jun 25	Burrows Scott L	Chief Financial Officer	MEXER	15,000	$14.50	$217.5K	+15.3%	Open the original filing on SEC.gov
Jun 23	Fairmount Funds…	Director	CCONV◆	16,667	—	—	—	Open the original filing on SEC.gov
Jun 23	Fairmount Funds…	Director	SSELL	4.7M	$85.31	$399.7M	-100.0%	Open the original filing on SEC.gov
Jun 23	Fairmount Funds…	Director	CCONV	666,680	—	—	+16.6%	Open the original filing on SEC.gov
Jun 22	Henderson Michael Thomas	Director	SSELL◷	20,000	$100.00	$2M	-22.6%	Open the original filing on SEC.gov
Jun 3	Sloan Sheldon	Chief Medical Officer	MEXER◷◆	8,333	—	—	—	Open the original filing on SEC.gov
Jun 3	Sloan Sheldon	Chief Medical Officer	SSELL◷	8,333	$75.00	$625K	-100.0%	Open the original filing on SEC.gov
Jun 3	Sloan Sheldon	Chief Medical Officer	MEXER◷	8,333	$27.46	$228.8K	—	Open the original filing on SEC.gov
Jun 1	Turtle Cameron	Chief Executive Officer	SSELL◷	3,294	$71.38	$235.1K	-0.5%	Open the original filing on SEC.gov
Jun 1	Turtle Cameron	Chief Executive Officer	SSELL◷	8,149	$70.50	$574.5K	-1.3%	Open the original filing on SEC.gov
Jun 1	Turtle Cameron	Chief Executive Officer	SSELL◷	3,557	$69.40	$246.9K	-0.6%	Open the original filing on SEC.gov
Jun 1	Burrows Scott L	Chief Financial Officer	MEXER◷◆	7,500	—	—	—	Open the original filing on SEC.gov
Jun 1	Burrows Scott L	Chief Financial Officer	SSELL◷	3,100	$72.06	$223.4K	-3.1%	Open the original filing on SEC.gov
Jun 1	Burrows Scott L	Chief Financial Officer	SSELL◷	2,599	$70.77	$183.9K	-2.5%	Open the original filing on SEC.gov
Jun 1	Burrows Scott L	Chief Financial Officer	SSELL◷	1,801	$69.75	$125.6K	-1.7%	Open the original filing on SEC.gov
Jun 1	Burrows Scott L	Chief Financial Officer	MEXER◷	7,500	$14.50	$108.8K	+7.6%	Open the original filing on SEC.gov
May 27	Stelzer Laurie	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 27	Milligan Sandra	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 27	McKenna Mark C.	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 27	Henderson Michael Thomas	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 27	Fairmount Funds…	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 27	Albers Jeffrey W.	Director	AGRANT◆	8,026	—	—	—	Open the original filing on SEC.gov
May 8	Henderson Michael Thomas	Director	SSELL◷	19,269	$75.35	$1.5M	-17.9%	Open the original filing on SEC.gov
May 8	Henderson Michael Thomas	Director	SSELL◷	24,814	$74.76	$1.9M	-18.7%	Open the original filing on SEC.gov
May 8	Henderson Michael Thomas	Director	SSELL◷	33,513	$73.72	$2.5M	-20.2%	Open the original filing on SEC.gov
May 8	Henderson Michael Thomas	Director	SSELL◷	2,404	$72.57	$174.5K	-1.4%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	300	$74.96	$22.5K	<0.1%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	1,700	$74.23	$126.2K	-0.3%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	3,100	$73.14	$226.7K	-0.5%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	1,000	$71.76	$71.8K	-0.2%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	3,600	$70.77	$254.8K	-0.6%	Open the original filing on SEC.gov
May 1	Turtle Cameron	Chief Executive Officer	SSELL◷	5,300	$69.54	$368.6K	-0.8%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	MEXER◷◆	78,333	—	—	—	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	400	$75.37	$30.1K	-100.0%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	5,059	$74.60	$377.4K	-92.7%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	10,358	$73.74	$763.8K	-65.5%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	12,777	$72.94	$932K	-44.7%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	8,777	$71.56	$628.1K	-23.5%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	19,656	$70.61	$1.4M	-34.5%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	SSELL◷	21,306	$69.53	$1.5M	-27.2%	Open the original filing on SEC.gov
May 1	Sloan Sheldon	Chief Medical Officer	MEXER◷	78,333	$27.46	$2.2M	—	Open the original filing on SEC.gov
May 1	Burrows Scott L	Chief Financial Officer	MEXER◷◆	12,500	—	—	—	Open the original filing on SEC.gov
May 1	Burrows Scott L	Chief Financial Officer	SSELL◷	12,500	$71.37	$892.1K	-11.3%	Open the original filing on SEC.gov
May 1	Burrows Scott L	Chief Financial Officer	MEXER◷	12,500	$14.50	$181.3K	+12.8%	Open the original filing on SEC.gov

MEXER◷◆—

Albers Jeffrey W. · DirectorAug 7

5,000 sh

SSELL◷$1M

Albers Jeffrey W. · DirectorAug 7

10,000 sh @ $104.68 · -51.6% own

SSELL◷$835K

Albers Jeffrey W. · DirectorAug 7

8,000 sh @ $104.38 · -29.2% own

SSELL◷$522.4K

Albers Jeffrey W. · DirectorAug 7

5,000 sh @ $104.47 · -100.0% own

MEXER◷$52K

Albers Jeffrey W. · DirectorAug 7

5,000 sh @ $10.39

SSELL◷$1.6K

Turtle Cameron · Chief Executive…Aug 3

16 sh @ $97.46 · 0.0% own

SSELL◷$134.8K

Turtle Cameron · Chief Executive…Aug 3

1,392 sh @ $96.82 · -0.2% own

SSELL◷$540.6K

Turtle Cameron · Chief Executive…Aug 3

5,635 sh @ $95.93 · -1.0% own

SSELL◷$680.6K

Turtle Cameron · Chief Executive…Aug 3

7,157 sh @ $95.10 · -1.2% own

SSELL◷$75.2K

Turtle Cameron · Chief Executive…Aug 3

800 sh @ $93.97 · -0.1% own

MEXER◷◆—

Burrows Scott L · Chief Financial…Aug 3

7,500 sh

SSELL◷$9.7K

Burrows Scott L · Chief Financial…Aug 3

100 sh @ $97.10 · -0.1% own

SSELL◷$221.5K

Burrows Scott L · Chief Financial…Aug 3

2,300 sh @ $96.30 · -2.3% own

SSELL◷$485.6K

Burrows Scott L · Chief Financial…Aug 3

5,100 sh @ $95.21 · -4.8% own

MEXER◷$108.8K

Burrows Scott L · Chief Financial…Aug 3

7,500 sh @ $14.50 · +7.6% own

SSELL◷$52.5K

Turtle Cameron · Chief Executive…Jul 1

590 sh @ $88.91 · -0.1% own

SSELL◷$373.1K

Turtle Cameron · Chief Executive…Jul 1

4,234 sh @ $88.12 · -0.7% own

SSELL◷$889.8K

Turtle Cameron · Chief Executive…Jul 1

10,176 sh @ $87.44 · -1.7% own

MEXER◷◆—

Sloan Sheldon · Chief Medical…Jul 1

8,334 sh

SSELL◷$162K

Sloan Sheldon · Chief Medical…Jul 1

1,834 sh @ $88.34 · -100.0% own

SSELL◷$568.9K

Sloan Sheldon · Chief Medical…Jul 1

6,500 sh @ $87.52 · -78.0% own

MEXER◷$228.9K

Sloan Sheldon · Chief Medical…Jul 1

8,334 sh @ $27.46

MEXER◷◆—

Burrows Scott L · Chief Financial…Jul 1

7,500 sh

SSELL◷$152.4K

Burrows Scott L · Chief Financial…Jul 1

1,725 sh @ $88.37 · -1.7% own

SSELL◷$505.6K

Burrows Scott L · Chief Financial…Jul 1

5,775 sh @ $87.55 · -5.5% own

MEXER◷$108.8K

Burrows Scott L · Chief Financial…Jul 1

7,500 sh @ $14.50 · +7.6% own

MEXER◆—

Burrows Scott L · Chief Financial…Jun 25

15,000 sh

SSELL$871.4K

Burrows Scott L · Chief Financial…Jun 25

10,000 sh @ $87.14 · -9.3% own

SSELL$435.6K

Burrows Scott L · Chief Financial…Jun 25

5,000 sh @ $87.12 · -4.4% own

MEXER$217.5K

Burrows Scott L · Chief Financial…Jun 25

15,000 sh @ $14.50 · +15.3% own

CCONV◆—

Fairmount Funds… · DirectorJun 23

16,667 sh

SSELL$399.7M

Fairmount Funds… · DirectorJun 23

4.7M sh @ $85.31 · -100.0% own

CCONV—

Fairmount Funds… · DirectorJun 23

666,680 sh · +16.6% own

SSELL◷$2M

Henderson Michael Thomas · DirectorJun 22

20,000 sh @ $100.00 · -22.6% own

MEXER◷◆—

Sloan Sheldon · Chief Medical…Jun 3

8,333 sh

SSELL◷$625K

Sloan Sheldon · Chief Medical…Jun 3

8,333 sh @ $75.00 · -100.0% own

MEXER◷$228.8K

Sloan Sheldon · Chief Medical…Jun 3

8,333 sh @ $27.46

SSELL◷$235.1K

Turtle Cameron · Chief Executive…Jun 1

3,294 sh @ $71.38 · -0.5% own

SSELL◷$574.5K

Turtle Cameron · Chief Executive…Jun 1

8,149 sh @ $70.50 · -1.3% own

SSELL◷$246.9K

Turtle Cameron · Chief Executive…Jun 1

3,557 sh @ $69.40 · -0.6% own

MEXER◷◆—

Burrows Scott L · Chief Financial…Jun 1

7,500 sh

SSELL◷$223.4K

Burrows Scott L · Chief Financial…Jun 1

3,100 sh @ $72.06 · -3.1% own

SSELL◷$183.9K

Burrows Scott L · Chief Financial…Jun 1

2,599 sh @ $70.77 · -2.5% own

SSELL◷$125.6K

Burrows Scott L · Chief Financial…Jun 1

1,801 sh @ $69.75 · -1.7% own

MEXER◷$108.8K

Burrows Scott L · Chief Financial…Jun 1

7,500 sh @ $14.50 · +7.6% own

AGRANT◆—

Stelzer Laurie · DirectorMay 27

8,026 sh

AGRANT◆—

Milligan Sandra · DirectorMay 27

8,026 sh

AGRANT◆—

McKenna Mark C. · DirectorMay 27

8,026 sh

AGRANT◆—

Henderson Michael Thomas · DirectorMay 27

8,026 sh

AGRANT◆—

Fairmount Funds… · DirectorMay 27

8,026 sh

AGRANT◆—

Albers Jeffrey W. · DirectorMay 27

8,026 sh

SSELL◷$1.5M

Henderson Michael Thomas · DirectorMay 8

19,269 sh @ $75.35 · -17.9% own

SSELL◷$1.9M

Henderson Michael Thomas · DirectorMay 8

24,814 sh @ $74.76 · -18.7% own

SSELL◷$2.5M

Henderson Michael Thomas · DirectorMay 8

33,513 sh @ $73.72 · -20.2% own

SSELL◷$174.5K

Henderson Michael Thomas · DirectorMay 8

2,404 sh @ $72.57 · -1.4% own

SSELL◷$22.5K

Turtle Cameron · Chief Executive…May 1

300 sh @ $74.96 · <0.1% own

SSELL◷$126.2K

Turtle Cameron · Chief Executive…May 1

1,700 sh @ $74.23 · -0.3% own

SSELL◷$226.7K

Turtle Cameron · Chief Executive…May 1

3,100 sh @ $73.14 · -0.5% own

SSELL◷$71.8K

Turtle Cameron · Chief Executive…May 1

1,000 sh @ $71.76 · -0.2% own

SSELL◷$254.8K

Turtle Cameron · Chief Executive…May 1

3,600 sh @ $70.77 · -0.6% own

SSELL◷$368.6K

Turtle Cameron · Chief Executive…May 1

5,300 sh @ $69.54 · -0.8% own

MEXER◷◆—

Sloan Sheldon · Chief Medical…May 1

78,333 sh

SSELL◷$30.1K

Sloan Sheldon · Chief Medical…May 1

400 sh @ $75.37 · -100.0% own

SSELL◷$377.4K

Sloan Sheldon · Chief Medical…May 1

5,059 sh @ $74.60 · -92.7% own

SSELL◷$763.8K

Sloan Sheldon · Chief Medical…May 1

10,358 sh @ $73.74 · -65.5% own

SSELL◷$932K

Sloan Sheldon · Chief Medical…May 1

12,777 sh @ $72.94 · -44.7% own

SSELL◷$628.1K

Sloan Sheldon · Chief Medical…May 1

8,777 sh @ $71.56 · -23.5% own

SSELL◷$1.4M

Sloan Sheldon · Chief Medical…May 1

19,656 sh @ $70.61 · -34.5% own

SSELL◷$1.5M

Sloan Sheldon · Chief Medical…May 1

21,306 sh @ $69.53 · -27.2% own

MEXER◷$2.2M

Sloan Sheldon · Chief Medical…May 1

78,333 sh @ $27.46

MEXER◷◆—

Burrows Scott L · Chief Financial…May 1

12,500 sh

SSELL◷$892.1K

Burrows Scott L · Chief Financial…May 1

12,500 sh @ $71.37 · -11.3% own

MEXER◷$181.3K

Burrows Scott L · Chief Financial…May 1

12,500 sh @ $14.50 · +12.8% own

Filing record

How quickly insiders here report their trades. Section 16 allows two business days from the transaction.

All 16 filings we hold were filed within the two-business-day deadline.

Counted in business days from the transaction date, or the deemed execution date where the filing reports one, excluding weekends and federal holidays. How this is measured · All late filings

Insiders at this company

Everyone who has filed a Form 4 for this issuer.