KPTI

Karyopharm Therapeutics Inc.

Insider trading activity for Karyopharm Therapeutics Inc., straight from SEC Form 4 filings. Net figures below count open-market buys and sales only — grants, option exercises and tax withholding are excluded because they are compensation, not decisions to trade.

Past 3 months

-$1.4K

net selling

Bought(0 · 0 insiders): $0
Sold(2 · 2 insiders): $1.4K

Past 6 months

-$40.1K

net selling

Bought(0 · 0 insiders): $0
Sold(9 · 6 insiders): $40.1K

Past 12 months

-$351.6K

net selling

Bought(0 · 0 insiders): $0
Sold(20 · 7 insiders): $351.6K

Transaction history

The 69 most recent Form 4 transactions.

Open in screener →

Insider transactions, newest first: date, security, transaction type, size and a link to the filing each row came from.
Date	Insider	Role	Type	Shares	Price	Value	Δ Own	Filing
Sep 1	Abate Kristin	Chief Accounting Officer	SSELL	19	$2.02	$38	<0.1%	Open the original filing on SEC.gov
Jul 28	Poulton Stuart	EVP, Chief Development…	SSELL	189	$7.10	$1.3K	-0.2%	Open the original filing on SEC.gov
May 21	Su Zhen	Director	AGRANT	15,508	—	—	—	Open the original filing on SEC.gov
May 21	Oliger Christy J.	Director	AGRANT	15,508	—	—	—	Open the original filing on SEC.gov
May 21	Schor Chen	Director	AGRANT	15,508	—	—	—	Open the original filing on SEC.gov
May 21	Pakianathan Deepika	Director	AGRANT	15,508	—	—	—	Open the original filing on SEC.gov
May 21	Greene Barry E	Director	AGRANT	15,508	—	—	+1,710%	Open the original filing on SEC.gov
May 21	Bohlin Garen G	Director	AGRANT	15,508	—	—	+515.4%	Open the original filing on SEC.gov
May 14	Poulton Stuart	EVP, Chief Development…	SSELL	403	$9.50	$3.8K	-0.4%	Open the original filing on SEC.gov
May 14	Rangwala Reshma	EVP & Chief Medical…	SSELL	408	$9.50	$3.9K	-0.7%	Open the original filing on SEC.gov
May 14	Paulson Richard A.	President and CEO	SSELL	2,203	$9.50	$20.9K	-0.8%	Open the original filing on SEC.gov
May 14	Mano Michael	EVP, CLO&Secretary	SSELL	266	$9.50	$2.5K	-0.3%	Open the original filing on SEC.gov
May 14	Cheng Sohanya Roshan	EVP & Chief Commercial…	SSELL	324	$9.50	$3.1K	-0.3%	Open the original filing on SEC.gov
May 14	Abate Kristin	Chief Accounting Officer	SSELL	53	$9.50	$504	-0.2%	Open the original filing on SEC.gov
May 13	Poulton Stuart	EVP, Chief Development…	AGRANT	896	—	—	+0.9%	Open the original filing on SEC.gov
May 13	Rangwala Reshma	EVP & Chief Medical…	AGRANT	947	—	—	+1.7%	Open the original filing on SEC.gov
May 13	Paulson Richard A.	President and CEO	AGRANT	4,920	—	—	+1.8%	Open the original filing on SEC.gov
May 13	Mano Michael	EVP, CLO&Secretary	AGRANT	700	—	—	+0.7%	Open the original filing on SEC.gov
May 13	Cheng Sohanya Roshan	EVP & Chief Commercial…	AGRANT	947	—	—	+0.9%	Open the original filing on SEC.gov
May 13	Abate Kristin	Chief Accounting Officer	AGRANT	121	—	—	+0.5%	Open the original filing on SEC.gov
Apr 21	Rangwala Reshma	EVP & Chief Medical…	SSELL	449	$8.94	$4K	-0.8%	Open the original filing on SEC.gov
Mar 2	Poulton Stuart	EVP, Chief Development…	SSELL	5,101	$9.41	$48K	-5.1%	Open the original filing on SEC.gov
Mar 2	Mano Michael	EVP, CLO&Secretary	SSELL	3,526	$9.41	$33.2K	-3.6%	Open the original filing on SEC.gov
Mar 2	Rangwala Reshma	EVP & Chief Medical…	SSELL	5,066	$9.41	$47.7K	-8.2%	Open the original filing on SEC.gov
Mar 2	Paulson Richard A.	President and CEO	SSELL	12,361	$9.41	$116.3K	-4.4%	Open the original filing on SEC.gov
Mar 2	Cheng Sohanya Roshan	EVP & Chief Commercial…	SSELL	4,604	$9.41	$43.3K	-4.1%	Open the original filing on SEC.gov
Mar 2	Abate Kristin	Chief Accounting Officer	SSELL	559	$9.41	$5.3K	-2.5%	Open the original filing on SEC.gov
Feb 17	Poulton Stuart	EVP, Chief Development…	SSELL	378	$8.63	$3.3K	-0.4%	Open the original filing on SEC.gov
Feb 5	Paulson Richard A.	President and CEO	AGRANT	81,060	—	—	+40.9%	Open the original filing on SEC.gov
Feb 3	Macomber Lori	EVP, CFO & Treasurer	SSELL	1,626	$6.30	$10.2K	-1.9%	Open the original filing on SEC.gov
Jan 31	Rangwala Reshma	EVP & Chief Medical…	AGRANT	32,415	—	—	+110.3%	Open the original filing on SEC.gov
Jan 31	Macomber Lori	EVP, CFO & Treasurer	AGRANT	32,415	—	—	+59.7%	Open the original filing on SEC.gov
Jan 31	Mano Michael	EVP, CLO&Secretary	AGRANT	32,415	—	—	+49.8%	Open the original filing on SEC.gov
Jan 31	Poulton Stuart	EVP, Chief Development…	AGRANT	32,415	—	—	+48.1%	Open the original filing on SEC.gov
Jan 31	Cheng Sohanya Roshan	EVP & Chief Commercial…	AGRANT	32,415	—	—	+40.8%	Open the original filing on SEC.gov
Jan 28	Abate Kristin	Chief Accounting Officer	SSELL	50	$7.03	$352	-0.2%	Open the original filing on SEC.gov
Jan 27	Abate Kristin	Chief Accounting Officer	AGRANT	92	—	—	+0.4%	Open the original filing on SEC.gov
Jan 21	Abate Kristin	Chief Accounting Officer	SSELL	265	$5.96	$1.6K	-1.2%	Open the original filing on SEC.gov
Oct 15, 2025	Poulton Stuart	EVP, Chief Development…	AGRANT	39,682	—	—	+143.2%	Open the original filing on SEC.gov
Oct 15, 2025	Mano Michael	SVP, General Counsel&Sec…	AGRANT	43,650	—	—	+203.7%	Open the original filing on SEC.gov
Oct 15, 2025	Paulson Richard A.	President and CEO	AGRANT	114,285	—	—	+136.0%	Open the original filing on SEC.gov
Oct 15, 2025	Macomber Lori	EVP, CFO & Treasurer	AGRANT	43,650	—	—	+409.2%	Open the original filing on SEC.gov
Oct 15, 2025	Cheng Sohanya Roshan	EVP & Chief Commercial…	AGRANT	43,650	—	—	+121.7%	Open the original filing on SEC.gov
Oct 15, 2025	Abate Kristin	Chief Accounting Officer	AGRANT	12,799	—	—	+127.4%	Open the original filing on SEC.gov
Oct 1, 2025	Abate Kristin	Chief Accounting Officer	SSELL	362	$6.30	$2.3K	-3.5%	Open the original filing on SEC.gov
Sep 15, 2025	Paulson Richard A.	President and CEO	SSELL	1,257	$6.43	$8.1K	-1.5%	Open the original filing on SEC.gov
Sep 15, 2025	Mano Michael	SVP, General Counsel&Sec…	SSELL	234	$6.43	$1.5K	-1.1%	Open the original filing on SEC.gov
Sep 15, 2025	Poulton Stuart	EVP, Chief Development…	SSELL	401	$6.43	$2.6K	-1.4%	Open the original filing on SEC.gov
Sep 15, 2025	Rangwala Reshma	EVP & Chief Medical…	SSELL	408	$6.43	$2.6K	-1.4%	Open the original filing on SEC.gov
Sep 15, 2025	Cheng Sohanya Roshan	EVP & Chief Commercial…	SSELL	325	$6.43	$2.1K	-0.9%	Open the original filing on SEC.gov
Sep 15, 2025	Abate Kristin	Chief Accounting Officer	SSELL	23	$6.43	$148	-0.2%	Open the original filing on SEC.gov
Sep 12, 2025	Paulson Richard A.	President and CEO	AGRANT	2,800	—	—	+3.4%	Open the original filing on SEC.gov
Sep 12, 2025	Mano Michael	SVP, General Counsel&Sec…	AGRANT	612	—	—	+2.9%	Open the original filing on SEC.gov
Sep 12, 2025	Poulton Stuart	EVP, Chief Development…	AGRANT	888	—	—	+3.3%	Open the original filing on SEC.gov
Sep 12, 2025	Rangwala Reshma	EVP & Chief Medical…	AGRANT	945	—	—	+3.3%	Open the original filing on SEC.gov
Sep 12, 2025	Cheng Sohanya Roshan	EVP & Chief Commercial…	AGRANT	945	—	—	+2.7%	Open the original filing on SEC.gov
Sep 12, 2025	Abate Kristin	Chief Accounting Officer	AGRANT	46	—	—	+0.4%	Open the original filing on SEC.gov
Sep 3, 2025	Abate Kristin	Chief Accounting Officer	SSELL	12	$6.78	$81	-0.1%	Open the original filing on SEC.gov
Jul 29, 2025	Poulton Stuart	EVP, Chief Development…	SSELL	191	$4.37	$835	-0.7%	Open the original filing on SEC.gov
Jul 22, 2025	Abate Kristin	Chief Accounting Officer	SSELL	238	$4.00	$952	-2.5%	Open the original filing on SEC.gov
May 28, 2025	Su Zhen	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Pakianathan Deepika	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Oliger Christy J.	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Mirza Mansoor Raza	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Schor Chen	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Greene Barry E	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 28, 2025	Bohlin Garen G	Director	AGRANT◆	4,600	—	—	—	Open the original filing on SEC.gov
May 6, 2025	Paulson Richard A.	President and CEO	SSELL	236	$7.12	$1.7K	-0.3%	Open the original filing on SEC.gov
Apr 23, 2025	Rangwala Reshma	EVP & Chief Medical…	SSELL	419	$6.17	$2.6K	-1.4%	Open the original filing on SEC.gov

SSELL$38

Abate Kristin · Chief Accounting…Sep 1

19 sh @ $2.02 · <0.1% own

SSELL$1.3K

Poulton Stuart · EVP, Chief Develop…Jul 28

189 sh @ $7.10 · -0.2% own

AGRANT—

Su Zhen · DirectorMay 21

15,508 sh

AGRANT—

Oliger Christy J. · DirectorMay 21

15,508 sh

AGRANT—

Schor Chen · DirectorMay 21

15,508 sh

AGRANT—

Pakianathan Deepika · DirectorMay 21

15,508 sh

AGRANT—

Greene Barry E · DirectorMay 21

15,508 sh · +1,710% own

AGRANT—

Bohlin Garen G · DirectorMay 21

15,508 sh · +515.4% own

SSELL$3.8K

Poulton Stuart · EVP, Chief Develop…May 14

403 sh @ $9.50 · -0.4% own

SSELL$3.9K

Rangwala Reshma · EVP & Chief…May 14

408 sh @ $9.50 · -0.7% own

SSELL$20.9K

Paulson Richard A. · President and CEOMay 14

2,203 sh @ $9.50 · -0.8% own

SSELL$2.5K

Mano Michael · EVP, CLO&SecretaryMay 14

266 sh @ $9.50 · -0.3% own

SSELL$3.1K

Cheng Sohanya Roshan · EVP & Chief…May 14

324 sh @ $9.50 · -0.3% own

SSELL$504

Abate Kristin · Chief Accounting…May 14

53 sh @ $9.50 · -0.2% own

AGRANT—

Poulton Stuart · EVP, Chief Develop…May 13

896 sh · +0.9% own

AGRANT—

Rangwala Reshma · EVP & Chief…May 13

947 sh · +1.7% own

AGRANT—

Paulson Richard A. · President and CEOMay 13

4,920 sh · +1.8% own

AGRANT—

Mano Michael · EVP, CLO&SecretaryMay 13

700 sh · +0.7% own

AGRANT—

Cheng Sohanya Roshan · EVP & Chief…May 13

947 sh · +0.9% own

AGRANT—

Abate Kristin · Chief Accounting…May 13

121 sh · +0.5% own

SSELL$4K

Rangwala Reshma · EVP & Chief…Apr 21

449 sh @ $8.94 · -0.8% own

SSELL$48K

Poulton Stuart · EVP, Chief Develop…Mar 2

5,101 sh @ $9.41 · -5.1% own

SSELL$33.2K

Mano Michael · EVP, CLO&SecretaryMar 2

3,526 sh @ $9.41 · -3.6% own

SSELL$47.7K

Rangwala Reshma · EVP & Chief…Mar 2

5,066 sh @ $9.41 · -8.2% own

SSELL$116.3K

Paulson Richard A. · President and CEOMar 2

12,361 sh @ $9.41 · -4.4% own

SSELL$43.3K

Cheng Sohanya Roshan · EVP & Chief…Mar 2

4,604 sh @ $9.41 · -4.1% own

SSELL$5.3K

Abate Kristin · Chief Accounting…Mar 2

559 sh @ $9.41 · -2.5% own

SSELL$3.3K

Poulton Stuart · EVP, Chief Develop…Feb 17

378 sh @ $8.63 · -0.4% own

AGRANT—

Paulson Richard A. · President and CEOFeb 5

81,060 sh · +40.9% own

SSELL$10.2K

Macomber Lori · EVP, CFO & Treasur…Feb 3

1,626 sh @ $6.30 · -1.9% own

AGRANT—

Rangwala Reshma · EVP & Chief…Jan 31

32,415 sh · +110.3% own

AGRANT—

Macomber Lori · EVP, CFO & Treasur…Jan 31

32,415 sh · +59.7% own

AGRANT—

Mano Michael · EVP, CLO&SecretaryJan 31

32,415 sh · +49.8% own

AGRANT—

Poulton Stuart · EVP, Chief Develop…Jan 31

32,415 sh · +48.1% own

AGRANT—

Cheng Sohanya Roshan · EVP & Chief…Jan 31

32,415 sh · +40.8% own

SSELL$352

Abate Kristin · Chief Accounting…Jan 28

50 sh @ $7.03 · -0.2% own

AGRANT—

Abate Kristin · Chief Accounting…Jan 27

92 sh · +0.4% own

SSELL$1.6K

Abate Kristin · Chief Accounting…Jan 21

265 sh @ $5.96 · -1.2% own

AGRANT—

Poulton Stuart · EVP, Chief Develop…Oct 15, 2025

39,682 sh · +143.2% own

AGRANT—

Mano Michael · SVP, General…Oct 15, 2025

43,650 sh · +203.7% own

AGRANT—

Paulson Richard A. · President and CEOOct 15, 2025

114,285 sh · +136.0% own

AGRANT—

Macomber Lori · EVP, CFO & Treasur…Oct 15, 2025

43,650 sh · +409.2% own

AGRANT—

Cheng Sohanya Roshan · EVP & Chief…Oct 15, 2025

43,650 sh · +121.7% own

AGRANT—

Abate Kristin · Chief Accounting…Oct 15, 2025

12,799 sh · +127.4% own

SSELL$2.3K

Abate Kristin · Chief Accounting…Oct 1, 2025

362 sh @ $6.30 · -3.5% own

SSELL$8.1K

Paulson Richard A. · President and CEOSep 15, 2025

1,257 sh @ $6.43 · -1.5% own

SSELL$1.5K

Mano Michael · SVP, General…Sep 15, 2025

234 sh @ $6.43 · -1.1% own

SSELL$2.6K

Poulton Stuart · EVP, Chief Develop…Sep 15, 2025

401 sh @ $6.43 · -1.4% own

SSELL$2.6K

Rangwala Reshma · EVP & Chief…Sep 15, 2025

408 sh @ $6.43 · -1.4% own

SSELL$2.1K

Cheng Sohanya Roshan · EVP & Chief…Sep 15, 2025

325 sh @ $6.43 · -0.9% own

SSELL$148

Abate Kristin · Chief Accounting…Sep 15, 2025

23 sh @ $6.43 · -0.2% own

AGRANT—

Paulson Richard A. · President and CEOSep 12, 2025

2,800 sh · +3.4% own

AGRANT—

Mano Michael · SVP, General…Sep 12, 2025

612 sh · +2.9% own

AGRANT—

Poulton Stuart · EVP, Chief Develop…Sep 12, 2025

888 sh · +3.3% own

AGRANT—

Rangwala Reshma · EVP & Chief…Sep 12, 2025

945 sh · +3.3% own

AGRANT—

Cheng Sohanya Roshan · EVP & Chief…Sep 12, 2025

945 sh · +2.7% own

AGRANT—

Abate Kristin · Chief Accounting…Sep 12, 2025

46 sh · +0.4% own

SSELL$81

Abate Kristin · Chief Accounting…Sep 3, 2025

12 sh @ $6.78 · -0.1% own

SSELL$835

Poulton Stuart · EVP, Chief Develop…Jul 29, 2025

191 sh @ $4.37 · -0.7% own

SSELL$952

Abate Kristin · Chief Accounting…Jul 22, 2025

238 sh @ $4.00 · -2.5% own

AGRANT◆—

Su Zhen · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Pakianathan Deepika · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Oliger Christy J. · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Mirza Mansoor Raza · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Schor Chen · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Greene Barry E · DirectorMay 28, 2025

4,600 sh

AGRANT◆—

Bohlin Garen G · DirectorMay 28, 2025

4,600 sh

SSELL$1.7K

Paulson Richard A. · President and CEOMay 6, 2025

236 sh @ $7.12 · -0.3% own

SSELL$2.6K

Rangwala Reshma · EVP & Chief…Apr 23, 2025

419 sh @ $6.17 · -1.4% own

Filing record

How quickly insiders here report their trades. Section 16 allows two business days from the transaction.

All 56 filings we hold were filed within the two-business-day deadline.

Counted in business days from the transaction date, or the deemed execution date where the filing reports one, excluding weekends and federal holidays. How this is measured · All late filings

Insiders at this company

Everyone who has filed a Form 4 for this issuer.

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