DNLI

Denali Therapeutics Inc.

Insider trading activity for Denali Therapeutics Inc., straight from SEC Form 4 filings. Net figures below count open-market buys and sales only — grants, option exercises and tax withholding are excluded because they are compensation, not decisions to trade.

Past 3 months

-$435.3K

net selling

Bought(0 · 0 insiders): $0
Sold(5 · 3 insiders): $435.3K

Past 6 months

-$435.3K

net selling

Bought(0 · 0 insiders): $0
Sold(5 · 3 insiders): $435.3K

Past 12 months

-$1.3M

net selling

Bought(0 · 0 insiders): $0
Sold(7 · 4 insiders): $1.3M

Transaction history

The 63 most recent Form 4 transactions.

Open in screener →

Insider transactions, newest first: date, security, transaction type, size and a link to the filing each row came from.
Date	Insider	Role	Type	Shares	Price	Value	Δ Own	Filing
Sep 4	Chin Peter Scott	Chief Medical Officer	SSELL	1,654	$22.29	$36.9K	-0.8%	Open the original filing on SEC.gov
Sep 2	Thornberry Nancy	Director	SSELL◷	615	$23.74	$14.6K	-3.0%	Open the original filing on SEC.gov
Sep 2	Thornberry Nancy	Director	SSELL◷	10,824	$22.85	$247.3K	-34.8%	Open the original filing on SEC.gov
Sep 1	Schuth Alexander O.	COFO and Secretary	SSELL◷	2,768	$23.44	$64.9K	-1.0%	Open the original filing on SEC.gov
Aug 12	Watts Ryan J.	President and CEO	GGIFT	32,220	—	—	-1.5%	Open the original filing on SEC.gov
Aug 11	Schuth Alexander O.	COFO and Secretary	SSELL	2,857	$25.07	$71.6K	-1.0%	Open the original filing on SEC.gov
Jun 3	Van Hauwermeiren Timothy	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Van Hauwermeiren Timothy	Director	AGRANT	6,408	—	—	+60.3%	Open the original filing on SEC.gov
Jun 3	Thornberry Nancy	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Thornberry Nancy	Director	AGRANT	6,408	—	—	+25.9%	Open the original filing on SEC.gov
Jun 3	Krognes Steve E.	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Krognes Steve E.	Director	AGRANT	6,408	—	—	+20.2%	Open the original filing on SEC.gov
Jun 3	Schenkein David P	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Schenkein David P	Director	AGRANT	6,408	—	—	+42.0%	Open the original filing on SEC.gov
Jun 3	Klein Peter S	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Klein Peter S	Director	AGRANT	6,408	—	—	+23.3%	Open the original filing on SEC.gov
Jun 3	Flatley Jay T	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Flatley Jay T	Director	AGRANT	6,408	—	—	+39.5%	Open the original filing on SEC.gov
Jun 3	Cook Jennifer E.	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Cook Jennifer E.	Director	AGRANT	6,408	—	—	+24.6%	Open the original filing on SEC.gov
Jun 3	Baker Bros. Advisors Lp	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Baker Bros. Advisors Lp	Director	AGRANT◆	19,226	—	—	—	Open the original filing on SEC.gov
Jun 3	Baker Bros. Advisors Lp	Director	AGRANT	6,408	—	—	+0.2%	Open the original filing on SEC.gov
Jun 3	Baker Bros. Advisors Lp	Director	AGRANT	6,408	—	—	+1.9%	Open the original filing on SEC.gov
Jan 6	Schuth Alexander O.	COFO and Secretary	SSELL	17,218	$16.50	$284.1K	-5.7%	Open the original filing on SEC.gov
Jan 6	Watts Ryan J.	President and CEO	SSELL	35,198	$16.50	$580.8K	-10.6%	Open the original filing on SEC.gov
Jan 3	Schuth Alexander O.	COFO and Secretary	AGRANT◆	173,100	—	—	—	Open the original filing on SEC.gov
Jan 3	Schuth Alexander O.	COFO and Secretary	AGRANT	57,700	—	—	+23.8%	Open the original filing on SEC.gov
Jan 3	Watts Ryan J.	President and CEO	AGRANT◆	236,880	—	—	—	Open the original filing on SEC.gov
Jan 3	Watts Ryan J.	President and CEO	AGRANT	78,960	—	—	+31.2%	Open the original filing on SEC.gov
Dec 11, 2025	Baker Bros. Advisors Lp	Director	PDBUY◆	2.1M	$17.49	$36.6M	—	Open the original filing on SEC.gov
Dec 11, 2025	Baker Bros. Advisors Lp	Director	PDBUY◆	190,523	$17.49	$3.3M	—	Open the original filing on SEC.gov
Nov 4, 2025	Van Hauwermeiren Timothy	Director	AGRANT◆	31,897	—	—	—	Open the original filing on SEC.gov
Nov 4, 2025	Van Hauwermeiren Timothy	Director	AGRANT	10,632	—	—	—	Open the original filing on SEC.gov
Sep 3, 2025	Watts Ryan J.	President and CEO	GGIFT	50,000	—	—	-2.3%	Open the original filing on SEC.gov
Aug 13, 2025	Ho Carole	Chief Medical Officer	SSELL◷	806	$14.64	$11.8K	-0.4%	Open the original filing on SEC.gov
Aug 12, 2025	Schuth Alexander O.	COFO and Secretary	SSELL	2,937	$13.58	$39.9K	-1.2%	Open the original filing on SEC.gov
Aug 12, 2025	Ho Carole	Chief Medical Officer	SSELL◷	2,937	$13.58	$39.9K	-1.3%	Open the original filing on SEC.gov
Aug 5, 2025	Ho Carole	Chief Medical Officer	MEXER◆	44,655	—	—	—	Open the original filing on SEC.gov
Aug 5, 2025	Ho Carole	Chief Medical Officer	MEXER	44,655	$0.68	$30.4K	+25.4%	Open the original filing on SEC.gov
Jul 9, 2025	Watts Ryan J.	President and CEO	MEXER◷◆	40,000	—	—	—	Open the original filing on SEC.gov
Jul 9, 2025	Watts Ryan J.	President and CEO	MEXER◷◆	455,282	—	—	—	Open the original filing on SEC.gov
Jul 9, 2025	Watts Ryan J.	President and CEO	SSELL◷	495,282	$15.00	$7.4M	-66.2%	Open the original filing on SEC.gov
Jul 9, 2025	Watts Ryan J.	President and CEO	MEXER◷	40,000	$5.28	$211.2K	+5.7%	Open the original filing on SEC.gov
Jul 9, 2025	Watts Ryan J.	President and CEO	MEXER◷	455,282	$0.68	$309.6K	+179.9%	Open the original filing on SEC.gov
Jun 3, 2025	Flatley Jay T	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Flatley Jay T	Director	AGRANT	6,037	—	—	+59.3%	Open the original filing on SEC.gov
Jun 3, 2025	Klein Peter S	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Klein Peter S	Director	AGRANT	6,037	—	—	+28.1%	Open the original filing on SEC.gov
Jun 3, 2025	Krognes Steve E.	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Krognes Steve E.	Director	AGRANT	6,037	—	—	+23.4%	Open the original filing on SEC.gov
Jun 3, 2025	Schenkein David P	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Schenkein David P	Director	AGRANT	6,037	—	—	+65.5%	Open the original filing on SEC.gov
Jun 3, 2025	Thornberry Nancy	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Thornberry Nancy	Director	AGRANT	6,037	—	—	+32.3%	Open the original filing on SEC.gov
Jun 3, 2025	Tessier-Lavigne Marc	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Tessier-Lavigne Marc	Director	AGRANT	6,037	—	—	+0.3%	Open the original filing on SEC.gov
Jun 3, 2025	Cook Jennifer E.	Director	AGRANT◆	18,111	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Cook Jennifer E.	Director	AGRANT	6,037	—	—	+30.1%	Open the original filing on SEC.gov
Jun 3, 2025	Baker Bros. Advisors Lp	Director	AGRANT◆	31,695	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Baker Bros. Advisors Lp	Director	AGRANT◆	31,695	—	—	—	Open the original filing on SEC.gov
Jun 3, 2025	Baker Bros. Advisors Lp	Director	AGRANT	10,565	—	—	+0.3%	Open the original filing on SEC.gov
Jun 3, 2025	Baker Bros. Advisors Lp	Director	AGRANT	10,565	—	—	+3.2%	Open the original filing on SEC.gov

SSELL$36.9K

Chin Peter Scott · Chief Medical…Sep 4

1,654 sh @ $22.29 · -0.8% own

SSELL◷$14.6K

Thornberry Nancy · DirectorSep 2

615 sh @ $23.74 · -3.0% own

SSELL◷$247.3K

Thornberry Nancy · DirectorSep 2

10,824 sh @ $22.85 · -34.8% own

SSELL◷$64.9K

Schuth Alexander O. · COFO and SecretarySep 1

2,768 sh @ $23.44 · -1.0% own

GGIFT—

Watts Ryan J. · President and CEOAug 12

32,220 sh · -1.5% own

SSELL$71.6K

Schuth Alexander O. · COFO and SecretaryAug 11

2,857 sh @ $25.07 · -1.0% own

AGRANT◆—

Van Hauwermeiren Timothy · DirectorJun 3

19,226 sh

AGRANT—

Van Hauwermeiren Timothy · DirectorJun 3

6,408 sh · +60.3% own

AGRANT◆—

Thornberry Nancy · DirectorJun 3

19,226 sh

AGRANT—

Thornberry Nancy · DirectorJun 3

6,408 sh · +25.9% own

AGRANT◆—

Krognes Steve E. · DirectorJun 3

19,226 sh

AGRANT—

Krognes Steve E. · DirectorJun 3

6,408 sh · +20.2% own

AGRANT◆—

Schenkein David P · DirectorJun 3

19,226 sh

AGRANT—

Schenkein David P · DirectorJun 3

6,408 sh · +42.0% own

AGRANT◆—

Klein Peter S · DirectorJun 3

19,226 sh

AGRANT—

Klein Peter S · DirectorJun 3

6,408 sh · +23.3% own

AGRANT◆—

Flatley Jay T · DirectorJun 3

19,226 sh

AGRANT—

Flatley Jay T · DirectorJun 3

6,408 sh · +39.5% own

AGRANT◆—

Cook Jennifer E. · DirectorJun 3

19,226 sh

AGRANT—

Cook Jennifer E. · DirectorJun 3

6,408 sh · +24.6% own

AGRANT◆—

Baker Bros. Advisors Lp · DirectorJun 3

19,226 sh

AGRANT◆—

Baker Bros. Advisors Lp · DirectorJun 3

19,226 sh

AGRANT—

Baker Bros. Advisors Lp · DirectorJun 3

6,408 sh · +0.2% own

AGRANT—

Baker Bros. Advisors Lp · DirectorJun 3

6,408 sh · +1.9% own

SSELL$284.1K

Schuth Alexander O. · COFO and SecretaryJan 6

17,218 sh @ $16.50 · -5.7% own

SSELL$580.8K

Watts Ryan J. · President and CEOJan 6

35,198 sh @ $16.50 · -10.6% own

AGRANT◆—

Schuth Alexander O. · COFO and SecretaryJan 3

173,100 sh

AGRANT—

Schuth Alexander O. · COFO and SecretaryJan 3

57,700 sh · +23.8% own

AGRANT◆—

Watts Ryan J. · President and CEOJan 3

236,880 sh

AGRANT—

Watts Ryan J. · President and CEOJan 3

78,960 sh · +31.2% own

PDBUY◆$36.6M

Baker Bros. Advisors Lp · DirectorDec 11, 2025

2.1M sh @ $17.49

PDBUY◆$3.3M

Baker Bros. Advisors Lp · DirectorDec 11, 2025

190,523 sh @ $17.49

AGRANT◆—

Van Hauwermeiren Timothy · DirectorNov 4, 2025

31,897 sh

AGRANT—

Van Hauwermeiren Timothy · DirectorNov 4, 2025

10,632 sh

GGIFT—

Watts Ryan J. · President and CEOSep 3, 2025

50,000 sh · -2.3% own

SSELL◷$11.8K

Ho Carole · Chief Medical…Aug 13, 2025

806 sh @ $14.64 · -0.4% own

SSELL$39.9K

Schuth Alexander O. · COFO and SecretaryAug 12, 2025

2,937 sh @ $13.58 · -1.2% own

SSELL◷$39.9K

Ho Carole · Chief Medical…Aug 12, 2025

2,937 sh @ $13.58 · -1.3% own

MEXER◆—

Ho Carole · Chief Medical…Aug 5, 2025

44,655 sh

MEXER$30.4K

Ho Carole · Chief Medical…Aug 5, 2025

44,655 sh @ $0.68 · +25.4% own

MEXER◷◆—