AMLX

Amylyx Pharmaceuticals, Inc.

Insider trading activity for Amylyx Pharmaceuticals, Inc., straight from SEC Form 4 filings. Net figures below count open-market buys and sales only — grants, option exercises and tax withholding are excluded because they are compensation, not decisions to trade.

Past 3 months

-$3.5M

net selling

Bought(0 · 0 insiders): $0
Sold(12 · 5 insiders): $3.5M

Past 6 months

-$3.4M

net selling

Bought(1 · 1 insiders): $51.3K
Sold(12 · 5 insiders): $3.5M

Past 12 months

-$10.5M

net selling

Bought(2 · 1 insiders): $152.2K
Sold(37 · 5 insiders): $10.6M

Transaction history

The 80 most recent Form 4 transactions.

Open in screener →

Insider transactions, newest first: date, security, transaction type, size and a link to the filing each row came from.
Date	Insider	Role	Type	Shares	Price	Value	Δ Own	Filing
Sep 10	Cohen Joshua B	Co-Chief Executive…	SSELL	919	$33.15	$30.5K	<0.1%	Open the original filing on SEC.gov
Sep 10	Cohen Joshua B	Co-Chief Executive…	SSELL	29,545	$32.16	$950K	-0.8%	Open the original filing on SEC.gov
Sep 10	Klee Justin B.	Co-Chief Executive…	SSELL	1,439	$33.16	$47.7K	<0.1%	Open the original filing on SEC.gov
Sep 10	Klee Justin B.	Co-Chief Executive…	SSELL	29,025	$32.13	$932.6K	-0.8%	Open the original filing on SEC.gov
Sep 10	Mazzariello Gina	Chief Legal Officer	SSELL	11	$33.34	$367	<0.1%	Open the original filing on SEC.gov
Sep 10	Mazzariello Gina	Chief Legal Officer	SSELL	9,525	$32.46	$309.1K	-4.8%	Open the original filing on SEC.gov
Sep 10	Frates James M	Chief Financial Officer	SSELL	1,042	$33.23	$34.6K	-0.4%	Open the original filing on SEC.gov
Sep 10	Frates James M	Chief Financial Officer	SSELL	9,768	$32.27	$315.2K	-4.0%	Open the original filing on SEC.gov
Sep 10	Bedrosian Camille L	Chief Medical Officer	SSELL	2,081	$33.09	$68.9K	-0.7%	Open the original filing on SEC.gov
Sep 10	Bedrosian Camille L	Chief Medical Officer	SSELL	7,947	$32.21	$256K	-2.8%	Open the original filing on SEC.gov
Aug 31	Firestone Karen	Director	MEXER◆	25,000	—	—	—	Open the original filing on SEC.gov
Aug 31	Firestone Karen	Director	MEXER◆	25,000	—	—	—	Open the original filing on SEC.gov
Aug 31	Firestone Karen	Director	MEXER	25,000	$5.05	$126.3K	+27.2%	Open the original filing on SEC.gov
Aug 31	Firestone Karen	Director	MEXER	25,000	$1.76	$44K	+37.4%	Open the original filing on SEC.gov
Aug 18	Cohen Joshua B	Co-Chief Executive…	AGRANT	60,039	—	—	+1.7%	Open the original filing on SEC.gov
Aug 18	Bedrosian Camille L	Chief Medical Officer	AGRANT	22,807	—	—	+8.6%	Open the original filing on SEC.gov
Aug 18	Mazzariello Gina	Chief Legal Officer	AGRANT	21,284	—	—	+11.9%	Open the original filing on SEC.gov
Aug 18	Klee Justin B.	Co-Chief Executive…	AGRANT	60,039	—	—	+1.7%	Open the original filing on SEC.gov
Aug 18	Frates James M	Chief Financial Officer	AGRANT	22,807	—	—	+10.3%	Open the original filing on SEC.gov
Jul 10	Mazzariello Gina	Chief Legal Officer	SSELL◷	15,000	$17.61	$264.1K	-7.7%	Open the original filing on SEC.gov
Jul 9	Mazzariello Gina	Chief Legal Officer	SSELL◷	15,000	$18.32	$274.7K	-7.2%	Open the original filing on SEC.gov
Jun 4	Zeiher Bernhardt G	Director	AGRANT◆	24,372	—	—	—	Open the original filing on SEC.gov
Jun 4	Firestone Karen	Director	AGRANT◆	24,372	—	—	—	Open the original filing on SEC.gov
Jun 4	Quimi Daphne	Director	AGRANT◆	24,372	—	—	—	Open the original filing on SEC.gov
Jun 4	Milne George M Jr	Director	AGRANT◆	24,372	—	—	—	Open the original filing on SEC.gov
Jun 4	Fonteyne Paul R.	Director	AGRANT◆	24,372	—	—	—	Open the original filing on SEC.gov
May 21	Firestone Karen	Director	PBUY	3,800	$13.51	$51.3K	+6.0%	Open the original filing on SEC.gov
Mar 5	Cohen Joshua B	Co-Chief Executive…	AGRANT◆	373,295	—	—	—	Open the original filing on SEC.gov
Mar 5	Cohen Joshua B	Co-Chief Executive…	AGRANT	248,865	—	—	+7.5%	Open the original filing on SEC.gov
Mar 5	Mazzariello Gina	Chief Legal Officer	AGRANT◆	111,990	—	—	—	Open the original filing on SEC.gov
Mar 5	Mazzariello Gina	Chief Legal Officer	AGRANT	74,660	—	—	+55.5%	Open the original filing on SEC.gov
Mar 5	Frates James M	Chief Financial Officer	AGRANT◆	143,985	—	—	—	Open the original filing on SEC.gov
Mar 5	Frates James M	Chief Financial Officer	AGRANT	95,990	—	—	+58.0%	Open the original filing on SEC.gov
Mar 5	Klee Justin B.	Co-Chief Executive…	AGRANT◆	373,295	—	—	—	Open the original filing on SEC.gov
Mar 5	Klee Justin B.	Co-Chief Executive…	AGRANT	248,865	—	—	+7.5%	Open the original filing on SEC.gov
Mar 5	Bedrosian Camille L	Chief Medical Officer	AGRANT◆	143,985	—	—	—	Open the original filing on SEC.gov
Mar 5	Bedrosian Camille L	Chief Medical Officer	AGRANT	95,990	—	—	+56.7%	Open the original filing on SEC.gov
Mar 2	Klee Justin B.	Co-Chief Executive…	SSELL	29,282	$14.47	$423.8K	-0.9%	Open the original filing on SEC.gov
Mar 2	Cohen Joshua B	Co-Chief Executive…	SSELL	29,282	$14.48	$424.1K	-0.9%	Open the original filing on SEC.gov
Mar 2	Bedrosian Camille L	Chief Medical Officer	SSELL	6,461	$14.58	$94.2K	-3.7%	Open the original filing on SEC.gov
Mar 2	Frates James M	Chief Financial Officer	SSELL	7,909	$14.52	$114.9K	-4.6%	Open the original filing on SEC.gov
Mar 2	Mazzariello Gina	Chief Legal Officer	SSELL	6,844	$14.52	$99.4K	-4.8%	Open the original filing on SEC.gov
Feb 23	Mazzariello Gina	Chief Legal Officer	SSELL	3,419	$14.14	$48.4K	-2.4%	Open the original filing on SEC.gov
Feb 2	Frates James M	Chief Financial Officer	SSELL	3,557	$14.65	$52.1K	-2.0%	Open the original filing on SEC.gov
Feb 2	Cohen Joshua B	Co-Chief Executive…	SSELL	15,500	$14.68	$227.6K	-0.5%	Open the original filing on SEC.gov
Feb 2	Mazzariello Gina	Chief Legal Officer	SSELL	3,448	$14.65	$50.5K	-2.3%	Open the original filing on SEC.gov
Feb 2	Klee Justin B.	Co-Chief Executive…	SSELL	15,500	$14.69	$227.6K	-0.5%	Open the original filing on SEC.gov
Jan 16	Cohen Joshua B	Co-Chief Executive…	MEXER◆	2,818	—	—	—	Open the original filing on SEC.gov
Jan 16	Cohen Joshua B	Co-Chief Executive…	SSELL	1,974	$13.83	$27.3K	<0.1%	Open the original filing on SEC.gov
Jan 16	Cohen Joshua B	Co-Chief Executive…	MEXER	2,818	$7.57	$21.3K	+<0.1%	Open the original filing on SEC.gov
Jan 16	Klee Justin B.	Co-Chief Executive…	MEXER◆	2,847	—	—	—	Open the original filing on SEC.gov
Jan 16	Klee Justin B.	Co-Chief Executive…	SSELL	1,995	$13.89	$27.7K	<0.1%	Open the original filing on SEC.gov
Jan 16	Klee Justin B.	Co-Chief Executive…	MEXER	2,847	$7.57	$21.6K	+<0.1%	Open the original filing on SEC.gov
Jan 15	Cohen Joshua B	Co-Chief Executive…	MEXER◆	197,182	—	—	—	Open the original filing on SEC.gov
Jan 15	Cohen Joshua B	Co-Chief Executive…	SSELL	136,193	$13.59	$1.9M	-3.9%	Open the original filing on SEC.gov
Jan 15	Cohen Joshua B	Co-Chief Executive…	MEXER	197,182	$7.57	$1.5M	+5.9%	Open the original filing on SEC.gov
Jan 15	Klee Justin B.	Co-Chief Executive…	MEXER◆	197,153	—	—	—	Open the original filing on SEC.gov
Jan 15	Klee Justin B.	Co-Chief Executive…	SSELL	136,193	$13.58	$1.8M	-3.9%	Open the original filing on SEC.gov
Jan 15	Klee Justin B.	Co-Chief Executive…	MEXER	197,153	$7.57	$1.5M	+5.9%	Open the original filing on SEC.gov
Jan 12	Milne George M Jr	Director	GGIFT	17,780	—	—	-2.1%	Open the original filing on SEC.gov
Jan 6	Frates James M	Chief Financial Officer	SSELL	3,326	$11.11	$37K	-1.8%	Open the original filing on SEC.gov
Jan 6	Cohen Joshua B	Co-Chief Executive…	SSELL	7,715	$11.09	$85.6K	-0.2%	Open the original filing on SEC.gov
Jan 6	Klee Justin B.	Co-Chief Executive…	SSELL	7,715	$11.09	$85.6K	-0.2%	Open the original filing on SEC.gov
Dec 23, 2025	Firestone Karen	Director	PBUY★	8,100	$12.45	$100.8K	+14.7%	Open the original filing on SEC.gov
Dec 1, 2025	Bedrosian Camille L	Chief Medical Officer	SSELL	6,580	$14.35	$94.4K	-3.6%	Open the original filing on SEC.gov
Sep 30, 2025	Klee Justin B.	Co-Chief Executive…	SSELL	200	$15.01	$3K	<0.1%	Open the original filing on SEC.gov
Sep 30, 2025	Klee Justin B.	Co-Chief Executive…	SSELL	29,775	$14.37	$428K	-0.9%	Open the original filing on SEC.gov
Sep 30, 2025	Mazzariello Gina	Chief Legal Officer	SSELL	8,828	$14.58	$128.7K	-5.6%	Open the original filing on SEC.gov
Sep 30, 2025	Frates James M	Chief Financial Officer	SSELL	10,558	$14.65	$154.7K	-3.6%	Open the original filing on SEC.gov
Sep 30, 2025	Cohen Joshua B	Co-Chief Executive…	SSELL	200	$15.00	$3K	<0.1%	Open the original filing on SEC.gov
Sep 30, 2025	Cohen Joshua B	Co-Chief Executive…	SSELL	29,733	$14.34	$426.5K	-0.9%	Open the original filing on SEC.gov
Sep 30, 2025	Bedrosian Camille L	Chief Medical Officer	SSELL	12,039	$14.58	$175.5K	-6.2%	Open the original filing on SEC.gov
Aug 13, 2025	Mazzariello Gina	Chief Legal Officer	SSELL◷	15,000	$8.34	$125K	-8.7%	Open the original filing on SEC.gov
Aug 12, 2025	Mazzariello Gina	Chief Legal Officer	SSELL◷	15,000	$8.07	$121.1K	-8.0%	Open the original filing on SEC.gov
Jun 5, 2025	Fonteyne Paul R.	Director	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Firestone Karen	Director	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Quimi Daphne	Director	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Milne George M Jr	Director	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
Jun 5, 2025	Zeiher Bernhardt G	Director	AGRANT◆	25,000	—	—	—	Open the original filing on SEC.gov
May 22, 2025	Mazzariello Gina	Chief Legal Officer	GGIFT	1,000	—	—	-0.5%	Open the original filing on SEC.gov

SSELL$30.5K

Cohen Joshua B · Co-Chief Executive…Sep 10

919 sh @ $33.15 · <0.1% own

SSELL$950K

Cohen Joshua B · Co-Chief Executive…Sep 10

29,545 sh @ $32.16 · -0.8% own

SSELL$47.7K

Klee Justin B. · Co-Chief Executive…Sep 10

1,439 sh @ $33.16 · <0.1% own

SSELL$932.6K

Klee Justin B. · Co-Chief Executive…Sep 10

29,025 sh @ $32.13 · -0.8% own

SSELL$367

Mazzariello Gina · Chief Legal…Sep 10

11 sh @ $33.34 · <0.1% own

SSELL$309.1K

Mazzariello Gina · Chief Legal…Sep 10

9,525 sh @ $32.46 · -4.8% own

SSELL$34.6K

Frates James M · Chief Financial…Sep 10

1,042 sh @ $33.23 · -0.4% own

SSELL$315.2K

Frates James M · Chief Financial…Sep 10

9,768 sh @ $32.27 · -4.0% own

SSELL$68.9K

Bedrosian Camille L · Chief Medical…Sep 10

2,081 sh @ $33.09 · -0.7% own

SSELL$256K

Bedrosian Camille L · Chief Medical…Sep 10

7,947 sh @ $32.21 · -2.8% own

MEXER◆—

Firestone Karen · DirectorAug 31

25,000 sh

MEXER◆—

Firestone Karen · DirectorAug 31

25,000 sh

MEXER$126.3K

Firestone Karen · DirectorAug 31

25,000 sh @ $5.05 · +27.2% own

MEXER$44K

Firestone Karen · DirectorAug 31

25,000 sh @ $1.76 · +37.4% own

AGRANT—

Cohen Joshua B · Co-Chief Executive…Aug 18

60,039 sh · +1.7% own

AGRANT—

Bedrosian Camille L · Chief Medical…Aug 18

22,807 sh · +8.6% own

AGRANT—

Mazzariello Gina · Chief Legal…Aug 18

21,284 sh · +11.9% own

AGRANT—

Klee Justin B. · Co-Chief Executive…Aug 18

60,039 sh · +1.7% own

AGRANT—

Frates James M · Chief Financial…Aug 18

22,807 sh · +10.3% own

SSELL◷$264.1K

Mazzariello Gina · Chief Legal…Jul 10

15,000 sh @ $17.61 · -7.7% own

SSELL◷$274.7K

Mazzariello Gina · Chief Legal…Jul 9

15,000 sh @ $18.32 · -7.2% own

AGRANT◆—

Zeiher Bernhardt G · DirectorJun 4

24,372 sh

AGRANT◆—

Firestone Karen · DirectorJun 4

24,372 sh

AGRANT◆—

Quimi Daphne · DirectorJun 4

24,372 sh

AGRANT◆—

Milne George M Jr · DirectorJun 4

24,372 sh

AGRANT◆—

Fonteyne Paul R. · DirectorJun 4

24,372 sh

PBUY$51.3K

Firestone Karen · DirectorMay 21

3,800 sh @ $13.51 · +6.0% own

AGRANT◆—

Cohen Joshua B · Co-Chief Executive…Mar 5

373,295 sh

AGRANT—

Cohen Joshua B · Co-Chief Executive…Mar 5

248,865 sh · +7.5% own

AGRANT◆—

Mazzariello Gina · Chief Legal…Mar 5

111,990 sh

AGRANT—

Mazzariello Gina · Chief Legal…Mar 5

74,660 sh · +55.5% own

AGRANT◆—

Frates James M · Chief Financial…Mar 5

143,985 sh

AGRANT—

Frates James M · Chief Financial…Mar 5

95,990 sh · +58.0% own

AGRANT◆—

Klee Justin B. · Co-Chief Executive…Mar 5

373,295 sh

AGRANT—

Klee Justin B. · Co-Chief Executive…Mar 5

248,865 sh · +7.5% own

AGRANT◆—

Bedrosian Camille L · Chief Medical…Mar 5

143,985 sh

AGRANT—

Bedrosian Camille L · Chief Medical…Mar 5

95,990 sh · +56.7% own

SSELL$423.8K

Klee Justin B. · Co-Chief Executive…Mar 2

29,282 sh @ $14.47 · -0.9% own

SSELL$424.1K

Cohen Joshua B · Co-Chief Executive…Mar 2

29,282 sh @ $14.48 · -0.9% own

SSELL$94.2K

Bedrosian Camille L · Chief Medical…Mar 2

6,461 sh @ $14.58 · -3.7% own

SSELL$114.9K

Frates James M · Chief Financial…Mar 2

7,909 sh @ $14.52 · -4.6% own

SSELL$99.4K

Mazzariello Gina · Chief Legal…Mar 2

6,844 sh @ $14.52 · -4.8% own

SSELL$48.4K

Mazzariello Gina · Chief Legal…Feb 23

3,419 sh @ $14.14 · -2.4% own

SSELL$52.1K

Frates James M · Chief Financial…Feb 2

3,557 sh @ $14.65 · -2.0% own

SSELL$227.6K

Cohen Joshua B · Co-Chief Executive…Feb 2

15,500 sh @ $14.68 · -0.5% own

SSELL$50.5K

Mazzariello Gina · Chief Legal…Feb 2

3,448 sh @ $14.65 · -2.3% own

SSELL$227.6K

Klee Justin B. · Co-Chief Executive…Feb 2

15,500 sh @ $14.69 · -0.5% own

MEXER◆—

Cohen Joshua B · Co-Chief Executive…Jan 16

2,818 sh

SSELL$27.3K

Cohen Joshua B · Co-Chief Executive…Jan 16

1,974 sh @ $13.83 · <0.1% own

MEXER$21.3K

Cohen Joshua B · Co-Chief Executive…Jan 16

2,818 sh @ $7.57 · +<0.1% own

MEXER◆—

Klee Justin B. · Co-Chief Executive…Jan 16

2,847 sh

SSELL$27.7K

Klee Justin B. · Co-Chief Executive…Jan 16

1,995 sh @ $13.89 · <0.1% own

MEXER$21.6K

Klee Justin B. · Co-Chief Executive…Jan 16

2,847 sh @ $7.57 · +<0.1% own

MEXER◆—

Cohen Joshua B · Co-Chief Executive…Jan 15

197,182 sh

SSELL$1.9M

Cohen Joshua B · Co-Chief Executive…Jan 15

136,193 sh @ $13.59 · -3.9% own

MEXER$1.5M

Cohen Joshua B · Co-Chief Executive…Jan 15

197,182 sh @ $7.57 · +5.9% own

MEXER◆—

Klee Justin B. · Co-Chief Executive…Jan 15

197,153 sh

SSELL$1.8M

Klee Justin B. · Co-Chief Executive…Jan 15

136,193 sh @ $13.58 · -3.9% own

MEXER$1.5M

Klee Justin B. · Co-Chief Executive…Jan 15

197,153 sh @ $7.57 · +5.9% own

GGIFT—

Milne George M Jr · DirectorJan 12

17,780 sh · -2.1% own

SSELL$37K

Frates James M · Chief Financial…Jan 6

3,326 sh @ $11.11 · -1.8% own

SSELL$85.6K

Cohen Joshua B · Co-Chief Executive…Jan 6

7,715 sh @ $11.09 · -0.2% own

SSELL$85.6K

Klee Justin B. · Co-Chief Executive…Jan 6

7,715 sh @ $11.09 · -0.2% own

PBUY★$100.8K

Firestone Karen · DirectorDec 23, 2025

8,100 sh @ $12.45 · +14.7% own

SSELL$94.4K

Bedrosian Camille L · Chief Medical…Dec 1, 2025

6,580 sh @ $14.35 · -3.6% own

SSELL$3K

Klee Justin B. · Co-Chief Executive…Sep 30, 2025

200 sh @ $15.01 · <0.1% own

SSELL$428K

Klee Justin B. · Co-Chief Executive…Sep 30, 2025

29,775 sh @ $14.37 · -0.9% own

SSELL$128.7K

Mazzariello Gina · Chief Legal…Sep 30, 2025

8,828 sh @ $14.58 · -5.6% own

SSELL$154.7K

Frates James M · Chief Financial…Sep 30, 2025

10,558 sh @ $14.65 · -3.6% own

SSELL$3K

Cohen Joshua B · Co-Chief Executive…Sep 30, 2025

200 sh @ $15.00 · <0.1% own

SSELL$426.5K

Cohen Joshua B · Co-Chief Executive…Sep 30, 2025

29,733 sh @ $14.34 · -0.9% own

SSELL$175.5K

Bedrosian Camille L · Chief Medical…Sep 30, 2025

12,039 sh @ $14.58 · -6.2% own

SSELL◷$125K

Mazzariello Gina · Chief Legal…Aug 13, 2025

15,000 sh @ $8.34 · -8.7% own

SSELL◷$121.1K

Mazzariello Gina · Chief Legal…Aug 12, 2025

15,000 sh @ $8.07 · -8.0% own

AGRANT◆—

Fonteyne Paul R. · DirectorJun 5, 2025

25,000 sh

AGRANT◆—

Firestone Karen · DirectorJun 5, 2025

25,000 sh

AGRANT◆—

Quimi Daphne · DirectorJun 5, 2025

25,000 sh

AGRANT◆—

Milne George M Jr · DirectorJun 5, 2025

25,000 sh

AGRANT◆—

Zeiher Bernhardt G · DirectorJun 5, 2025

25,000 sh

GGIFT—

Mazzariello Gina · Chief Legal…May 22, 2025

1,000 sh · -0.5% own

Filing record

How quickly insiders here report their trades. Section 16 allows two business days from the transaction.

All 52 filings we hold were filed within the two-business-day deadline.

Counted in business days from the transaction date, or the deemed execution date where the filing reports one, excluding weekends and federal holidays. How this is measured · All late filings

Insiders at this company

Everyone who has filed a Form 4 for this issuer.

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